Resurfacing, reinforcement, replenishment...
The three different Artelon®
concepts have been developed, based on a logical approach to facilitate tissue
restoration. Depending on implant design and where in the body the Artelon®
scaffolds are implanted, different kinds
of tissues are formed, i e bone, tendons, ligaments, cartilage etc.
The sequence of events in the repair of
injured tissue is bleeding, inflammation, proliferation and remodelling.
Inflammation is a normal and necessary prerequisite for healing. Following the
tissue bleeding, a number of substances will remain in the tissue, making a
contribution in the later phases.
The
following sequence illustrates a tissue defect and an Artelon® scaffold
from implantation to newly formed tissue.
This is an
illustration of a tissue defect, in this case in bone, but the principle is the
same in soft tissue. Artelon® is implanted where the tissue is
missing. It absorbs blood cells and stabilizes the clot. Healing can begin.
Fibrin (white
threads in the illustration), which is important for the adhesion of various
cells, begins to form and at this stage the new tissue is very fragile and
needs the support of the Artelon® material to remodel and mature.
New tissue has been formed. Final remodelling may
continue for months, and possibly over a year, depending on the kind of tissue.
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